Collaborated with a group of the world’s premier scientists, professors, and professionals in the fields of neuroscience and neuroethics.

Synthesized new neuroscience knowledge into a research proposal for a cutting-edge neuroscience experiment.

Engaged in interactive activities with discussions about cognitive neuroscience and neuroethics in a cross-cultural setting through a biophysical lens.

Umaiyal Nathan

The Quarry Lane School

Class of 2024

Learn more about Umaiyal here.

Uma is very excited to be participating in the Advanced Medical Neuroscience Internship this summer, and is particularly looking forward to working with a neuropriming device and learning about deep brain stimulations.

As rising junior at The Quarry Lane School, Uma is a passionate student who is enrolled in many accelerated and Advanced Placement courses. Outside of school, she loves pursuing research at miRcore with the University of Michigan, and at the Associated Students Direct Research Program, where she is currently researching neurological biomarkers. She also enjoys tutoring younger students at her school. This year, she placed first in her category in UC Davis's Teen Biotech Challenge. She also loves music, and she has been playing the piano for eight years and dancing Bharathanatyam for seven.

For the next two years, Uma will be pursuing an International Baccalaureate Diploma. After high school, she would like to study in the East Coast and the UK, and pursue a career in medicine. Experiencing firsthand family members with Schizophrenia and her own more recent journey with mental health is what originally sparked her interest in neuroscience. Uma has ambitions to become a neurosurgeon, but would also like to continue pursuing research with regards to various neurological disorders, including Schizophrenia and Alzheimers.

Read more about Umaiyal's achievements here.




My Research ProposalThe goal of this study is to learn how different pulses per second in DBS Stimulation changes the reaction in the maximal chorea in HD.It is hypothesized that deep brain stimulation with a 150 Hertz (Hz) pulse frequency targeted to the globus pallidus interna (GPi) can help decrease the UHDRS-TMS rating in patients in the maximal chorea subscore.How does changing the pulse frequency of Deep Brain Stimulation (DBS) of the globus pallidus Internus (GPi) influence maximal chorea in patients with Early Intermediate Stage (Stage 2) Huntington's disease?


My Research Proposal PresentationView my research proposal presentation here.At the conclusion of the internship, I presented my research proposal to a panel of judges including Dr. James Giordano, Dr. Rachel Wurzman, and Dr. John Shook.In the Advanced Medical Neuroscience Internship, I worked directly with some of the world’s leading brain scientists to learn about neuroethics, neurocognitive health, and revolutionary developments in the field.


The Frontier of Neuroscience

Center for Functional and Molecular Imaging

The Center for Functional and Molecular Imaging (CFMI) at Georgetown is one of the world’s leading institutions with expertise in structural, functional, and brain imaging.

While visiting the CFMI, I met Dr. John VanMeter, Director of the Neuroimaging Corps at Georgetown University, who described to me the rationale, protocols, capabilities, and limitations of Functional Magnetic Resonance Imaging and tract tracing.

I not only learned about the science behind fMRI, but also had the opportunity to see the machine that possess a magnetic power of 30,000 times the strength of Earth’s magnetic field.

Neuromodulation

Neuromodulation is a technology that electrically stimulates nerves or chemically targets neurological sites to treat nearly any disease or symptom.

I specifically learned about the HALO device, an application of neuromodulation that provides external electrical stimulation through a helmet of electrodes. It is primarily used to improve cognitive function and wellbeing, like learning, memory, and performance.

To further demonstrate the applications of neuromodulation, we learned aboutelectrical stimulation, perception of stimuli, and free will in order to control cockroaches from an iPhone.



Internship Highlights

Dr. James Giordano

Deep Brain Stimulation

The Creative Brain

Experts & Mentors

I had the chance to work and collaborate directly with Dr. James Giordano, Chief of Georgetown University’s Neuroethics Studies Program.

In addition to his involvement with a variety of educational institutions, Dr. Giordano is the author of over 350 publications in neuroscience and neuroethics.

During our first meeting, Dr. Giordano guided us through an exploration of our own brains, minds, and selves, probing for the problems, meanings, and questions within the world that surrounds us.

In subsequent meetings, Dr. Giordano frequently prompted both introspection and extrospection to encourage familiarity with the our own minds, as well as our environment, and how the two can interact to our benefit.

I had the unique opportunity to learn from Dr. Michael Okun, a neurologist, neuroscientist, and founder of the University of Florida’s Movement Disorders Program.

The university’s program aims to provide interdisciplinary and integrated care that facilitates communication between all members of their team to provide the best care possible.

Within his work, Dr. Okun utilizes Deep Brain Stimulation (DBS), which operates like a pacemaker within the brain and is often inserted via conscious surgery.

During this operation, electrodes are put in the brain to regulate electrical signals and help with conditions like Epilepsy, Parkinson’s Disease, Dystonia, Obsessive Compulsive Disorder, and Essential Tremor.

I had the opportunity to discuss stimulating creativity through brain science with Dr. Adam Green, the Director of the Lab for Relartional Cognition at Georgetown University.

Dr. Green maintains that creative insights are “the product of connections made between things other people didn’t put together,” and we explored the neurological foundations of this theory.

In one of his most prominent experiments, Dr. Green had participants draw the analogies to evaluate semantic distance and creativity as explained above, but also regarded the potential role of neuromodulation.

tDCS is transcranial direct current stimulation, which is a non-invasive "helmet" of sorts that allows for the modification of the neural pathways' firing in the brain. The external stimulator is placed on the scalp and then provides electrical stimulation to a broad region in order to control the neurons' firing.

Along with Dr. Giordano, I had the opportunity to work closely with Dr. Rachel Wurzman, a Fellow with the Center for Neuroscience & Society and Postdoctoral Research Fellow in Neurology with the Laboratory of Neural Stimulation at the University of Pennsylvania.

Dr. Wurzman promoted us to think critically about the questions that help drive science forwards and improve our understanding of the world around us biopsychosocially. She also lent her expertise of neuroplasticity, neurodiversity, and neuroethics to help our team develop our research proposal.

In addition to our work with Dr. Wurzman, we had the opportunity to meet with a variety of neuroscientists with a variety of unique specialities.

One such professional was Dr. Bill Casebear, a Lieutenant Colonel in the US Air Force, who holds a joint PhD in cognitive science and philosophy. Dr. Casebear used his expertise to discuss using neuroscience to drive policy, public health, and social responses for global issues and generate sustainable peace