NeuroCharissaWagner

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Charissa Wagner

Carrollwood Day School
Class of 2025

Collaborated with a group of the world’s premier researchers, professors, and professionals in the fields of neuroscience and neuroethics.

Synthesized new neuroscience knowledge into an ethical analysis for cutting-edge neuroscience research.

Engaged in interactive, cross-cultural activities and discussions about cognitive neuroscience and neuroethics through a biopsychosocial lens.

Learn more about Charissa here.

Charissa Wagner has always had an interest in how the brain works. Her younger brother has always developed differently and was borderline on the spectrum. She has watched him grow and see the things that come easy to us..be unbelievably hard for him. Then, her grandmother was in an accident with massive brain trauma while Charissa was studying neurotransmitters for her chemistry class. The combination of the three cemented her desire to learn more. The Advanced Medical Neuroscience Internship looks to provide insight into how neurons fire, how the brain is impacted, and true data on cognitive function like memory and processing speeds.

Charissa is a multi-national champion in competitive cheer. From her dedication to that sport, she has learned the power of teamwork, building trust, and how to set goals. She’s taken those tenets to help establish a student-led organization called “See Us Now. That organization advocates for safe, consistent foster housing on Capitol Hill. Her team has helped craft a bill and is advocating for two more. She has won two Presidential Volunteer Service Gold Medals and a Points of Light Award for her efforts. Charissa also teaches a life-skills class, is a member of the Beta Club, National Honors Society, the Spanish National Honors Society, the Entrepreneurship Business Investment team, and is President of Acteens. Charissa has also worked to help those impacted by natural disasters. She helps collect and distribute supplies, clean up homes, and feed those in need. This teen also enjoys time traveling and playing tennis, golf, and pickleball. She hopes to take her life lessons to help others in the future.

As an advocate for safe, consistent foster housing, Charissa is excited to work with Dr. Giordano, the Co-Director of the O’Neill-Pellegrino program in Brain Science and Global Health Law and Policy. As Charissa has researched the impact of the nomadic lifestyle of foster children, she has seen increased rates in PTSD, depression, and drug use. She is also enthusiastic to learn how the brain works and what we can do to improve function, mood, and connectivity among the population.

Read more about Charissa’s achievements here.

My Ethical Investigation Research

My research delved into crucial inquiries and ramifications pertinent to the exploration of Resolving Learning Disorder Injustices through Neuromodulation and its prospective trajectory. We transitioned from what neuroscience enables to what it morally necessitates.   

Neuromodulation technology shows promising potential in enhancing cognitive abilities, particularly for individuals with below-average function due to socioeconomic factors. This approach involves directly influencing neural pathways through techniques like EEG and TES to improve cognitive performance. However, ethical considerations are complex and multifaceted. Concerns include potential side effects on developing brains, such as impacts on creativity and identity, as well as unequal access exacerbating social disparities. Issues of informed consent, privacy regarding brain data, and the ethical implications of enhancing cognition in minors also require careful consideration. Stricter regulations are crucial to ensure fair distribution, ethical use, and safeguarding against potential misuse or coercion, thereby balancing the transformative benefits of neuromodulation with ethical responsibilities.

My Ethical Analysis
Presentation

In the Advanced Medical Neuroscience Internship, I worked directly with some of the world’s leading scientists to learn about neuroethics, neurocognitive health, and revolutionary developments in the field.

I had the honor of presenting my research to a distinguished panel of judges, among them Dr. James Giordano, Chief of Georgetown University’s Neuroethics Studies Program. 

My presentation aimed to engage in discourse and shed light on the ethical considerations inherent in reviewing research about Resolving Learning Disorder Injustices through Neuromodulation for the esteemed judges.

The Frontier of Neuroscience

Center for Functional and Molecular Imaging

The Center for Functional and Molecular Imaging (CFMI) at Georgetown is one of the world’s leading institutions with expertise in structural, functional, and brain imaging.

While visiting the CFMI, I met Dr. Ashley VanMeter, Director of the Neuroimaging Corps at Georgetown University, who described to me the rationale, protocols, capabilities, and limitations of functional magnetic resonance imaging for clinical and basic science applications.

I not only learned about the science behind fMRI, but also had the opportunity to see a machine that possesses a magnetic power of 30,000 times the strength of Earth’s magnetic field.

Neuromodulation

Neuromodulation is a technology that electrically stimulates nerves or chemically targets neurological sites to treat a vast array of conditions and symptoms. 

I specifically learned about transcranial direct current stimulation and the neuromodulation devices available for public purchase. These technologies provide external electrical stimulation through a helmet or headband of electrodes.

To further demonstrate the applications of neuromodulation, we learned about electrical stimulation, perception of stimuli, and used the electrical activity captured from flexing my own muscle to contract the muscle of another intern. Through this, we could control each other’s arms!

Internship Highlights

I had the chance to work and collaborate directly with Dr. James Giordano, Chief of Georgetown University’s Neuroethics Studies Program. 

In addition to his involvement with a variety of educational institutions, Dr. Giordano is the author of over 350 publications in neuroscience and neuroethics.

During our first meeting, Dr. Giordano guided us through an exploration of our own brains, minds, and selves, probing for the problems, meanings, and questions within the world that surrounds us.

In subsequent meetings, Dr. Giordano frequently prompted both introspection and extrospection to encourage familiarity with our own minds, as well as our environment, and how the two can interact to our benefit.

I had the unique opportunity to learn from Dr. Michael Okun, a neurologist, neuroscientist, and founder of the University of Florida’s Movement Disorders Program. 

The university’s program aims to provide interdisciplinary and integrated care that facilitates communication between all members of their team to provide the best care possible.

Within his work, Dr. Okun utilizes Deep Brain Stimulation (DBS), which operates like a pacemaker within the brain and is often inserted via conscious surgery.

During this operation, electrodes are put in the brain to regulate electrical signals and help with conditions like Epilepsy, Parkinson’s Disease, Dystonia, Obsessive Compulsive Disorder, and Essential Tremor.

I had the opportunity to discuss stimulating creativity through brain science with Dr. Adam Green, the Director of the Lab for Relational Cognition at Georgetown University.

Dr. Green maintains that creative insights are “the product of connections made between things other people didn’t put together,” and we explored the neurological foundations of this theory.

In one of his most prominent experiments, Dr. Green had participants draw the analogies to evaluate semantic distance and creativity as explained above, but also regarded the potential role of neuromodulation.

tDCS is transcranial direct current stimulation, which is a non-invasive “helmet” of sorts that allows for the modification of the neural pathways’ firing in the brain. The external stimulator is placed on the scalp and then provides electrical stimulation to a broad region in order to control the neurons’ firing. We also had  a chance to observe and try neurofeedback technology that uses how we learn to help us train our brains in real time!

Along with Dr. Giordano, I had the opportunity to work closely with Dr. Rachel Wurzman, a Dana Foundation Fellow in Neuroscience and Society. 

Dr. Wurzman encouraged us to think critically about the questions that help drive science forwards and improve our understanding of the world around us through a biopsychosocial lens. She also lent her expertise of neuroplasticity, neurodiversity, and neuroethics to help our team develop our research proposal. 

In addition to our work with Dr. Wurzman, we had the opportunity to meet with a variety of neuroscientists with a variety of unique specialities. 

One such professional was Dr. Fernando Pagan, a Georgetown Neurologist and the Director of Movement Disorders, who is a nationally recognized leader in Parkinson’s Disease treatment. We were able to learn about Movement Disorders from various perspectives as Dr. Pagan was joined by Captain Rick Schena, who lives with Parkinson’s and explains how his treatment plan allows him to still do what he would like to do.